South Carolina Highway 417 is a numbered highway in Central Greenville and Spartanburg counties.

SC 417's western terminus is at junction with US 276 in Mauldin, SC and near the junctions of I-385 and I-185. Its overall course is in a northeasterly direction, and SC 417's eastern terminus is at a junction with SC 296 near Spartanburg, SC.

From SC 417's western terminus to its split from SC 14, SC 417 is known as Main St/Laurens Rd. From then until its merger with SC 146, SC 417 is known as Lee Vaughn Road. While it is merged with SC 146, SC 417 is known as Woodruff Rd. When it splits from SC 146, SC 417 is known as Highway 417, and it keeps that name until it reaches its eastern terminus.