In the U.S. state of Nevada, U.S. Route 93 (US 93) is a major United States Highway traversing the eastern edge of the state. The highway connects the Las Vegas area to the Great Basin National Park, and provides further connections to Ely and Wells. US 93 also provides the majority of the most direct connection between the major metropolitan areas of Las Vegas and Phoenix (via Boulder City, Kingman and Wickenburg with a final link to Phoenix via US 60).

U.S. Route 93 was not one of the original U.S. highways proposed in the 1925 Bureau of Public Roads plan. However, the revised numbering plan approved by the American Association of State Highway Officials (AASHO) on November 11, 1926 established US 93 from the Canadian border near Eureka, Montana south through Montana and Idaho to a southern terminus at Wells, Nevada. The establishment of the highway was reflected on Nevada's 1927 official highway map. The Nevada section was approximately 70 miles (110 km), commissioned along what was then the northern portion of State Route 13.

AASHO, at its June 8, 1931 meeting, approved a southerly extension of US 93 south to Glendale, Nevada. By 1932, the Nevada Department of Highways had marked the continuation of the highway using the routing of several preexisting state highways as follows:

At the request of the Arizona State Highway Department, the AASHO route numbering committee approved another extension of US 93 in 1935. This shifted the southern terminus south to Kingman, Arizona by way of Las Vegas. However, Nevada officials may not have signed the extension of US 93 right away, since it was not shown on state-published maps until 1939. The highway was again extended along existing highways:

The new routing put the Nevada mileage of U.S. Route 93 at approximately 540 miles (870 km). The entire highway within Nevada was paved by 1939.

After US 93 was extended to Arizona in the 1930s, the route remained unchanged for many years. A 19-mile (31 km) concurrency with U.S. Route 95 between Las Vegas and Alunite was added in 1940, when that highway was extended through southern Nevada along State Route 5.

The first major shift of US 93 occurred in 1967, when a new highway connection was completed between US 91 (now I-15) and a point 24 miles (39 km) northwest of Glendale. The new alignment was oriented more north–south, shortening the distance between the Las Vegas area and Caliente by 23 miles (37 km) . The old section of US 93 northwest of Glendale paralleling the Muddy River remained as State Route 7, and was renumbered in 1976 to State Route 168.

In 1982, a "truck bypass" along the upper reaches of Hemenway Wash, to skirt the central portion of Boulder City and allow a straighter, more steady climb for commercial vehicles, was nearing completion. But by the time this new route opened, it had been signed as mainline US 93, with the old, winding route of US 93 on the Nevada Highway (original SR 26) through town being changed to SR 500. This state highway designation was later dropped and that roadway is now maintained by Boulder City as "Nevada Way". The western end of this 1982 bypass was also later realigned from Colorado Street south to intersect directly at Buchanan Boulevard (in place of a wye intersection with Nevada Way a block to the east at Joshua Street), by using a small portion of abandoned railroad right-of-way. A shopping center now sits where the original truck bypass alignment once ran.

US 93 was realigned again on October 19, 2010, when the Mike O'Callaghan – Pat Tillman Memorial Bridge over the Black Canyon of the Colorado River opened to vehicular traffic. With that, the highway no longer passes over Hoover Dam, and the state-maintained portion of the replaced route was renamed as Hoover Dam Access Road (SR 172). In 2011, US 93 from Buchanan Boulevard to the Nevada terminus of the Hoover Dam Bypass was expanded to four through lanes with dedicated turn lanes at major intersections to better handle increased traffic loads from the new Hoover Dam Bypass until its long-planned companion freeway around Boulder City can be completed.