Maryland Route 373 (Accokeek Road) is a state highway in Prince George's County. It begins at the intersection with MD 210 and Livingston Road. It runs east through the unincorporated communities of Accokeek and Brandywine and crosses over MD 5 (Branch Avenue) before terminating at the county-maintained portion of Brandywine Road. This configuration is subject to change in the future depending on the results of a MDSHA project to revamp the MD 5 / MD 373 / Brandywine Road interchange.

It is a two-lane highway that carries an East/West designation and it runs for a total length of 8.18 miles (13.16 km).

Maryland Route 373 begins at the intersection with MD 210 (Indian Head Highway) and Livingston Road, near a shopping center in Accokeek. It runs east through a largely wooded residential area, intersecting Accokeek Road. Livingston Road continues to the northwest as MD 373 continues eastward on Accokeek Road, curving north and then east again at two incarnations of Bealle Hill Road. As the development of the unincorporated community eases off, the route enters farmland and passes by the northern edge of a golf course. The route passes through large forested areas, sometimes broken up by agricultural fields, and serves mostly homes along this stretch as it continues toward Brandywine. Here, the route intersects MD 5 (Branch Avenue) and continues a short stretch later where it terminates at the county-maintained portion of Brandywine Road.

Notable points of interest on or near Route 373 include:

The entire route is in Prince George's County.