Arkansas Highway 143 is a state highway of 10.08 miles (16.22 km) in Arkansas. It is a short route entirely in Carroll County.

AR 143 begins at US 62 north of AR 980 to the Carroll County Airport. The route runs north through Grandview and Pleasant Ridge to the Missouri state line. The route continues as Supplemental Route H north to Missouri Route 86.

The entire route is in Carroll County.

The route was paved from US 62 to Grandview in 1974, with the remainder being bituminous surface/gravel. The entire routing was paved by 1988.