North Carolina Highway 28 is a primary state highway in the state of North Carolina. The highway runs north–south through the Nantahala National Forest in Western North Carolina.

NC 28 is part of a three-state highway 28, that totals 238 miles (383 km), from Beech Island, South Carolina to Deals Gap.

NC 28 starts at the Georgia state line in Macon County. Southward the road continues as Georgia 28. This is the sole state highway that keeps its exact number as it crosses between Georgia and North Carolina. (NC 60 may also be considered to sort-of keep its route. It continues in Georgia as Spur 60. Mainline Georgia 60 meets the state line some miles to the west).

From the state line, it follows a winding course northwards to Highlands. There it begins a 14-mile (23 km) concurrency with US 64 on the way west to Franklin. From Franklin it leaves US 64 and travels north/northwest, mostly following the Little Tennessee River valley. There is a 3-mile (4.8 km) concurrency with US 74 between the unincorporated communities of Lauada and Needmore. From Needmore, it follows a westerly course along the southern shore of man-made Fontana Lake. A side road crosses the TVA constructed Fontana Dam; NC 28 skirts the southern boundary of the Great Smokey Mountains National Park before reaching its northern terminus at US 129.

NC 28 is part of two scenic byways in the state (indicated by a Scenic Byways sign).

Waterfall Byway is an 98-mile (158 km) byway from Murphy to Rosman; it is known for its more than 200 waterfalls that surround the route. NC 28 overlaps with US 64 between Franklin and Highlands; passing by Lake Sequoyah, Dry Falls, Bridal Veil Falls, and Cullsaja Gorge. Tractor-Trailers are prohibited on this road and it is also not recommended for recreational vehicles or buses.

Indian Lake Scenic Byway is an 60-mile (97 km) byway from Topton to Almond; it is known for scenic views along the banks of the Nantahala River, Little Tennessee River, and Cheoah River. It also features the Fontana Dam, Cheoah Dam, Santeetlah Dam, the grave of Junaluska, and the Tail of the Dragon. NC 28 shares half the route with US 129 (From Deals Gap to Almond). This route is not recommended for recreational vehicles or buses.

Established in 1930 as a new primary routing from the Georgia state line to Highlands. In 1938, NC 282 was replaced by NC 28.

Established as an original state highway in 1921, NC 286 began at the Georgia state line, near Otto, to NC 10, along Old Alarka Road. In 1927, NC 286 was renumbered as an extension of NC 285, from the Georgia state line to Franklin. Around 1938, NC 286 was replaced by NC 28 and moved the to north terminus to the community of Swain (today known as Lauada).