South Carolina Highway 59 (SC 59) is a state highway in the northwestern part of the U.S. state of South Carolina. The highway runs 15.6 miles (25.1 km) in a south-north orientation from just southwest of Fair Play north and then northeast to Seneca.

SC 59 begins at an interchange with I-85 just southwest of Fair Play. The route heads northeast into town, and intersects SC 182/SC 243. After leaving Fair Play, SC 59 heads northwest and turns to the northwest to intersect SC 24. The road heads on its northeast trajectory until it meets its northern terminus, at an intersection with US 76/US 123 in Seneca.

The entire route is in Oconee County.