State Route 221 or SR-221 is a 6.381-mile (10.269 km) long route that serves as a western bypass of Camden in Wilcox County.

The southern terminus of SR-221 is located at its intersection with SR-41 to the southwest of Camden. From this point, the route travels in a northward direction on a two-lane undivided road, passing through a mix of farms and woods. The road passes to the east of Camden Municipal Airport before coming to an intersection with SR-10. Following this, SR-221 continues north through wooded areas with some homes. The route runs through a mix of farmland and woodland before coming to its northern terminus at SR-28 northwest of Camden at Canton Bend.

The entire route is in Wilcox County.