Arkansas Highway 219 is a designation for two state highways in Franklin County, Arkansas. The southern segment of 1.50 miles (2.41 km) runs from Citadel Bible College northeast to Ozark. A northern segment of 10.88 miles (17.51 km) runs from U.S. Route 64 through Ozark northeast to Missouri state line.

AR 219 begins in Ozark at US 64 near the Ozark Courthouse Square Historic District, which is listed on the National Register of Historic Places listings in Franklin County, Arkansas. The route runs north through Ozark, including a junction with Airport Rd, which provides access to the Ozark-Franklin County Airport. AR 219 continues north over Interstate 40 to intersect AR 352 in Mountain Grove. After Mountain Grove, AR 219 continues north to terminate at County Road 312 near a church in rural Franklin County. The road is entirely two-lane undivided.

AR 219 begins at County Road 71 near Citadel Bible College and runs north to terminate at US 64. This portion does not cross or concur with any other state highways. The route is near the Arkansas River, and is a curved, narrow, two-lane road for its entire length.

The entire route is in Franklin County.

The entire route is in Franklin County.

The first appearance of Arkansas Highway 219 on the state highway map is the January 1966 edition, which numbers a gravel road from Ozark north to an area around Mountain Top as AR 219. The route was paved around 1963, and again most recently in 1975. The shorter route was added to the state highway system in 1966. The route has not been repaved or reconstructed since its addition to the state highway system.