State Route 169 (SR 169) is a state highway in northern the U.S. state of California.

The route begins at U.S. Route 101 near Klamath and after a discontinuity from Klamath Glen (near the McBeth Airport) to Johnsons via the Yurok Indian Reservation, resumes at the town of Wautec. The highway continues through Pacwan before the curving road heads southeast and passes through Martins Ferry after several miles. SR 169 ends at State Route 96 near Weitchpec. The entire route is within the Yurok Indian Reservation.

Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, and do not necessarily reflect current mileage. The numbers reset at county lines; the start and end postmiles in each county are given in the county column.