State Route 220 is a state highway in the U.S. state of California, defined to run between State Route 84 and State Route 160 on Ryer Island. At the eastern end of Ryer Island, the road crosses Steamboat Slough on the J-Mack Ferry, a cable ferry.

The route begins at State Route 84 in Solano County. It then heads eastward and follows the Howard Landing Ferry across the Steamboat Slough to its east end at State Route 160 in Sacramento County.

Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, and do not necessarily reflect current mileage. The numbers reset at county lines; the start and end postmiles in each county are given in the county column.