State Highway 75 is a Colorado highway in Jefferson and Arapahoe counties.

SH 75 runs a total of 3.7 miles (6.0 km) in two discontinuous segments. The highway starts at the intersection of Broadway and Rafferty Gardens Ave. in Englewood, and runs south on Broadway to Littleton Ave in Littleton. Although no longer a state highway, the route continues west on Littleton Ave and W. Bowles to Lowell Blvd where the second segment of SH 75 starts. SH 75 runs southwest from that point on S. Platte Canyon Rd. to a junction with SH 470 that allows access to only the westbound lanes.