State Route 60 is a north–south state highway that runs the entire length of the U.S. state of Ohio, from the Williamstown Bridge over the Ohio River in Marietta to U.S. Route 6 near Lake Erie in Vermilion.

Heading south from Vermilion, Route 60 traverses rural North Central Ohio while connecting Vermilion, New London, Ashland, and Loudonville. South of Loudonville, Route 60 enters more hilly country, before entering the Muskingum River Valley at Dresden. It closely parallels the Muskingum River for the remainder of its journey to Marietta except for an 11 miles (18 km) stretch in Morgan County where it moves inland to avoid bends in the river.

Markers for State Route 60 are not posted south of the Greene Street/3rd Street intersection in Marietta, the location of State Route 26's southern terminus. State Route 60 is unsigned along State Route 7/State Route 26/Greene Street and the Williamstown Bridge approach.

Parts of State Route 60 were once signed as State Route 77. In order to eliminate confusion with an interstate highway in Ohio having the same number, State Route 77 was renumbered in part as State Route 60.