State Route 295 (SR 295, OH 295) is a north–south state highway in northwestern Ohio, a U.S. state. Its southern terminus is an intersection with SR-65 in Grand Rapids. Its northern terminus is at the Michigan State Line in Berkey. The roadway continues into the Wolverine State as county-maintained Silberhorn Highway.

State Route 295 exists primarily within Lucas County with a southern terminus just inside the Wood County line. No portion of this state highway is included within the National Highway System.

Making its debut in 1932, State Route 295 was originally routed from its current eastern junction with State Route 2 to its current northern terminus at the Michigan State Line in Berkey. One year later, the highway would be extended southward to State Route 64 on the outskirts of Whitehouse. By 1935, State Route 295 was extended southward one more time, this time to a southern terminus at U.S. Route 24. The southern terminus of State Route 295 was at a T-intersection with U.S. Route 24 approximately 5 miles (8.0 km) southwest of Waterville until August 2012 when US-24 was rerouted. SR-295 was extended to run along the former US-24's alignment until Grand Rapids, where SR-295 then replaced the former SR-578 and terminates at SR-65.

The entire route is in Lucas County.