Highway 72 (AR 72, Ark. 72, and Hwy. 72) is a designation for two east–west state highways in Benton County, Arkansas. A western route of 26.32 miles (42.36 km) runs east from Highway 43 at Maysville to U.S. Route 71 Business (US 71B) in Bentonville. A second route of 12.67 miles (20.39 km) begins at Interstate 540/US Route 71 (I-540/US 71) in Bentonville and runs northeast to US 62 near Avoca. The route is one of the original Arkansas state highways.

The route begins at Highway 43 in Maysville and runs east to Gravette. Highway 72 intersects Highway 59 in Gravette near the Kansas City Southern Railway Caboose No. 383 on the National Register of Historic Places. The highway continues east past the Banks House to Hiwasse, where the highway passes the Hiwasse Bank Building. Upon reaching Hiwasse Highway 72 has an officially designated exception of 0.52 miles (0.84 km) with Highway 279 near . The highway runs southeast into Centerton. Highway 72 has a junction with Highway 102 Business (Highway 102B) before entering Bentonville. In Bentonville the highway becomes Central Avenue, running east through subdivisions until meeting US 71B and terminating a few block west of the Bentonville town square.

Highway 72 begins at I-540/US 71 in Bentonville and runs northeast to Pea Ridge. The highway has an overlap with Highway 94 through Pea Ridge before turning southeast and runs through Pea Ridge National Military Park. South of the park Highway 72 terminates at US 62.

The entire route is in Benton County.

Between Bentonville and Gravette, Highway 72 follows a former alignment of U.S. Route 71. In the late 1990s Highway 72 was rerouted away from downtown Bentonville along US 71 BUS, Highway 102, and Highway 112.

Highway 72 Spur (AR 72B, Ark. 72B, and Hwy. 72B) is a former spur route in Bentonville. Its southern terminus was at an intersection with U.S. Route 71 (now U.S. Route 71 Business (Northwest Arkansas) ) with a northern terminus at an intersection with Arkansas Highway 72 (aka Central Ave) in Bentonville. Running a total distance of 1-mile (1.6 km), it was an older alignment of U.S. 71 and at one time was part of U.S. Route 71 Business (Bentonville, Arkansas).