Oregon Route 218 is an Oregon state highway that runs between the small towns of Shaniko and Fossil in north-central Oregon and is known as the Shaniko-Fossil Highway No. 291 (see Oregon highways and routes). OR 218 is a part of the Journey Through Time Scenic Byway, an Oregon state byway.

OR 218 is a fairly short rural highway. Its western terminus is in Wasco County, in the ghost town of Shaniko at U.S. Route 97. The road is very windy and hilly over its entire 43-mile (69 km) length and is a popular destination for motorcyclists. It runs through the small town of Antelope (population 50) and has a junction with OR 293 on the south end of town.

More mountainous terrain follows, and the highway crosses the John Day River into Wheeler County at Clarno. Just east of Clarno is the Clarno Unit of the John Day Fossil Beds National Monument. Between Clarno and Fossil (the largest town on the route, with a population of about 475), the road has several sharp curves, with a posted speed limit of 15 miles per hour (24 km/h) in several places. The eastern terminus is in Fossil at the junction of Washington Street and Seventh Street (OR 19).