Interstate 380 (abbreviated I-380) is a spur highway in northeast Pennsylvania that connects Interstate 80 with Interstate 81 and Interstate 84. The northern terminus of I-380 is at Interstate 81 at the Throop-Dunmore Interchange in Dunmore; the southern terminus is in Tunkhannock Township at the junction with Interstate 80. The entire length of the highway is 28.10 miles (45.22 km). Prior to receiving its current designation, I-380 was designated as Interstate 81E, a spur of I-81. It was also an east–west highway, but in 2002, when the Pennsylvania Department of Transportation renumbered its Interstate Highway system exit numbers, I-380 was re-designated as a north–south highway.

Interstate 380 begins at Interstate 80 in Tunkhannock Township. The highway passes Gouldsboro State Park and Tobyhanna Military Reservation just past exit 8. At exit 24, Interstate 380 merges with Interstate 84 and later ends at the interchange with Interstate 81.