Route 110 is a numbered State Highway running 6.1 miles (9.8 km) wholly within the town of South Kingstown in Rhode Island. It serves to connect the University of Rhode Island to points south via U.S. 1.

Route 110 begins at U.S. Route 1 near the village of Perryville in the town of South Kingstown. The route heads north for 7 miles (11 km) following Ministerial Road through the wetlands of the Great Swamp. Soon after crossing some railroad tracks, Route 110 ends at an intersection with Route 138 in the village of West Kingston

Route 110 was assigned to Ministerial Road by 1969.

The entire route is in South Kingstown, Washington County.