South Carolina Highway 46 (SC 46) is a 17.2 mile (27.7 km) state highway in Beaufort and Jasper counties in the Lowcountry region of South Carolina, connecting the rapidly growing communities of Bluffton and Hardeeville and serving as a parallel route to U.S. Highway 278.

From the eastern terminus at an intersection with U.S. 278, SC 46 travels southwest along Bluffton Road for about 1.6 miles, connecting the newer commercial areas of Bluffton with the original "square mile" or historic town center. SC 46 than makes a right onto May River Road, which it follows for approximately 8 miles until the traffic circle intersection with SC 170. SC 46 is cosigned with SC 170 for about 2.5 miles as it enters Jasper County. The Beaufort County portions of SC 46 are a designated state scenic byway, with marsh vistas and live oak canopies providing a quintessentially Lowcountry feel to the drive.

Shortly after crossing the county line, SC 46 leaves SC 170 and makes a right onto Plantation Road heading northwest to Hardeeville. Once in Hardeeville, SC 46 is known as Main Street, where it crosses under Interstate 95 without a direct interchange. A frontage road though connects SC 46 with U.S. Highway 17 provides interstate access via exit 5. SC 46 crosses U.S. 17 a mile after the I-95 overpass and immediately crosses a CSX railway crossing. Shortly thereafter, the route arrives at its western terminus upon reaching the high-speed intersection with U.S. Highway 321 in unincorporated West Hardeeville.