State Route 10 is a south–north route from the Alabama state line in Lincoln County, Tennessee to the Kentucky state line in Macon County

State Route 10 begins at the Alabama state line in Lincoln County, where it is concurrent to U.S. Route 231 and U.S. Route 431. The three routes travel northward until US-431 leaves the concurrency in Fayetteville. There State Route 10 intersects U.S. Route 64 as well. When State Route 10 enters Moore County, it travels parallel to the border with Lincoln County along Chestnut Ridge. Once in Bedford County, the route crosses the Duck River and enters Shelbyville, where there is an intersection with U.S. Route 41A. After passing Bomar Field, Shelbyville's airport, US-231 and SR-10 head to Murfreesboro along a path that is almost completely straight. Soon after, State Route 10 enters Wilson County and passes right through the middle of Cedars of Lebanon State Park. After going through Lebanon, U.S. Route 231 and State Route 10 cross the Cumberland River at Hunter's Point to enter Trousdale County. Near the small community of Walnut Grove, U.S. Route 231 leaves State Route 10, and it becomes concurrent with State Route 25. East of Hartsville, the two routes split. State Route 10 heads north into Macon County and ends at the Kentucky border after passing through Lafayette.