State Route 69 (abbreviated SR 69) is a state highway in West and Middle Tennessee that runs nearby to the Tennessee River for the majority of its length. SR 69 carries both primary and secondary highway designations and is primarily rural in nature.

The vast majority of this highway is two-lane with no access control. SR 69 overlaps U.S. Highway 641 from Interstate 40 to Paris and U.S. Highway 64 from Savannah to Crump. In Hardin County, there are two separate sections of this road due to the path of the Tennessee River through this area.

SR 69 is one of the few state highways in Tennessee that have a signed alternate route. SR 69A is approximately 27.09 miles (43.60 km) long with a northern terminus of Paris and a southern terminus of Camden. It serves the community of Big Sandy and provides access to rural northern Benton County and southeastern Henry County. SR 69A is a narrow and very curvy two-lane highway throughout its entire length. SR 69A is known as 'Old Highway 69' in Benton County and a few old mileposts still exist indicating '69' and on the bottom of the sign, as opposed to newer mileposts which indicate '69A'.

SR 69/SR 69A traverses the following counties shown in the table below.

SR 192 and SR 69A both represent old alignments of SR 69 in Benton County. There are also numerous other unsigned historical sections that are named 'Old Highway 69' in Benton & Decatur county. These alignments generally run nearby the present day SR 69 and most feature narrow roadway width and extensive curves.