State Route 243 or SR-243 is a 20-mile (32 km) long route that serves as a connection between State Route 195 west of Rabbittown, Alabama, United States, with U.S. Highway 43 and State Route 24 in Russellville.

The southern terminus of SR-243 is located at its intersection with State Route 195 west of Rabbittown. From this point, the route travels in a northeasterly direction to its northern terminus at its intersection with U.S. Highway 43 and State Route 24 in Russellville.