State Route 291 (SR-291) is a .89-mile (1.43 km) long route that serves as a connection between SR-759 and US-278/US-431 in the eastern section of Gadsden in Etowah County.

The southern terminus of SR-291 is located at the eastern terminus of SR-759. From this point, the route generally travels in a northerly direction before terminating at US-278/US-431 in Gadsden.

The entire route is in Gadsden, Etowah County.