Arkansas Highway 110 is the name of multiple state highways in Arkansas.

Arkansas Highway 110 is a state highway of 16.8 miles (27.0 km) that runs in Van Buren and Stone Counties.

AR 110 begins at US 65/AR 9 in Botkinburg. The route winds as a rural road into Stone County for 1.5 miles (2.4 km) before returning to Van Buren County and terminating at AR 9/AR 16 near Shirley. The route does not intersect any other state highways along its routing.

Arkansas Highway 110 (locally Shiloh Road) is a state highway of 3.15 miles (5.07 km) that runs in Cleburne County.

AR 110 begins at AR 16/AR 92 in Greers Ferry. The route runs south and then directly into Greers Ferry Lake.

This route may have originally continued further south, before Greers Ferry Lake was filled.

The entire route is in Cleburne County.

Arkansas Highway 110 is a state highway of 18.7 miles (30.1 km) that runs in Cleburne and White Counties.

Highway 110 begins on the east side of Greers Ferry Lake just outside the gates to Eden Isle. The road continues over the little dike into the county seat of Cleburne County, Heber Springs. In town it is concurrent with Arkansas Highway 25 Business for several blocks. Just east of town it intersects with AR 25 and AR 5 at a 4-way stop before continuing past Sugarloaf Mountain and crossing the Little Red River. The small town of Wilburn is 9 miles (14 km) from Heber Springs on the route. The highway ends in Pangburn at an intersection with AR 16.