State Route 33 (SR 33) is a state highway that runs south-to-north through portions of Thomas, Brooks, Colquitt, Worth, and Crisp counties in south-central Georgia. The route runs from its southern terminus at US 84 and SR 38 in Boston to its northern terminus at US 41 and SR 7 south of Cordele.

From its southern terminus in Boston at US 84/SR 38, SR 33 travels north to Pavo. After a brief concurrency in Pavo with SR 122, SR 33 continues north. South of Moultrie, SR 33 begins a concurrency with US 319 BUS. The two routes travel north, through downtown Moultrie. North of the city, US 319 BUS departs, and after a brief concurrency with SR 133, the route continues north to Sylvester. In Sylvester, SR 33 has a brief concurrency with SR 112 before departing and continuing north to its northern terminus at US 41/SR 7 south of Cordele.

A largely rural route, State Route 33 sees only minor traffic except in Moultrie. Much of the route sees an Average Annual Daily Traffic (AADT) of 2,000 vehicles or less.

State Route 33 Connector (SR 33 CONN) is a short connector route near Cordele. SR 33 CONN connects the SR 33 mainline, as well as US 41/SR 7, with I-75 via Rockbridge Road.