Interstate 110 (I-110) is a 0.92-mile (1.48 km) spur route in El Paso extending from Interstate 10, south along U.S. Highway 54, turns west then turns south into Mexico. Interstate 110 provides access from Interstate 10 to the Bridge of the Americas (A.K.A. Cordova Bridge in El Paso and Puente Libre in Mexico), which spans the Rio Grande to connect with Avenida Abraham Lincoln in Ciudad Juárez, Mexico. Interstate 110 is currently the only three-digit Interstate to connect directly with Mexico, and one of only two to connect to an international border, the other being Interstate 190 in New York.

I-110 is a short spur route of I-10 in El Paso that connects I-10 with the Cordova International Bridge at the United States-Mexico border. The southern end of the freeway begins at the northern end of the bridge and heads north passing under US 62. After the interchange with US 62, I-110 curves towards the east briefly before curving back towards the north at an interchange with US 54. I-110 begins to run concurrently with US 54 as the freeway heads north to an interchange with I-10. This expressway interchange is fairly complex, and has three levels worth of routes crossing. The locals have dubbed this interchange the "Spaghetti Bowl." I-110 ends at I-10 and the Spaghetti Bowl while the freeway continues to the north carrying the US 54 designation.

I-110 was officially designated as a route from I-10 to the Cordova International Bridge in 1967. The interchange at US 62 was completed in 1970. By 1972, the interchange at US 54 had been completed. The overpass at SH 20 as well as the interchange at I-10 was completed in 1973.

The entire route is in El Paso, El Paso County.