Kentucky Route 425 (or Henderson Bypass) is the Southern Beltline around Henderson, Kentucky. It is a two-lane road that runs from US 60/KY 136 east to Pennyrile Parkway (future I-69) and intersects with US 41A, KY 1299, and US 41. It is a rural highway that is all at grade intersections. At the US 41A Junction, rumble strips are used to alert traffic to the intersections.

KY 425 begins at an intersection with US 60/KY 136 west of Henderson, heading southeast on the two-lane undivided Henderson Bypass. The road passes through farmland with some development and comes to a bridge over an abandoned railroad line. The route curves east and comes to an intersection with US 41 Alt. KY 425 passes through more agricultural areas to the south of Henderson and intersects KY 1299. The road comes to a bridge over a CSX railroad line and crosses US 41/KY 136. The route curves northeast and widens into a divided highway as it comes to its eastern terminus at an interchange with the Pennyrile Parkway (future I-69).

Built in the 1980s, it connects KY 136 (Geneva Road) to the Pennyrile Parkway (Future I-69). It has gone under renovation for road repairs in late September to repair potholes. Being built in the '80s it is starting to show its age of pavement and bridges.

The entire route is in Henderson, Henderson County.