Maryland Route 288 (MD 288) is a state highway in the U.S. state of Maryland. Known as Crosby Road, the state highway runs 3.33 miles (5.36 km) from MD 20 in Rock Hall east to Long Cove Public Landing on the Piney Neck peninsula in western Kent County. MD 288 was constructed in the mid-1920s.

MD 288 begins at an intersection with MD 20 (Rock Hall Road) just east of Rock Hall. The state highway heads south through a mix of farmland and forest. At Skinners Neck Road, MD 288 turns east and then south again at Edesville Road. The state highway turns east again in the hamlet of Crosby while Piney Neck Road continues south. MD 288 veers south while McKinleyville Road continues southeast, reaching its eastern terminus at Long Cove Public Landing on Long Cove, an inlet of Langford Creek just north of where the creek empties into the Chester River.

MD 288 was constructed in 1925 and 1926. The highway has changed very little since then.

The entire route is in Kent County.