Mississippi Highway 5 (MS 5) is a state highway in Benton County, Mississippi. It runs 26.929 mi (43.338 km) from MS 178 in Hickory Flat north to U.S. Route 72 (US 72) to the south of Michigan City. The route runs through the Holly Springs National Forest for much of its length and passes through Ashland. To the south of Ashland, MS 5 has a concurrency with MS 4. The MS 5 designation was first used by 1932 for an unpaved road between Hickory Flat and the Tennessee border in Michigan City. In 1943, the northern terminus was cut back to US 72. MS 5 was completely paved by 1951 and has retained its current alignment since then.

MS 5 begins at an intersection with MS 178 in the community of Hickory Flat, which is within the Holly Springs National Forest. The route heads north from this point on a two-lane undivided road, passing a mix of trees, fields, and homes. After a junction with the western terminus of MS 2, MS 5 enters dense forests for the next several miles, passing a few residences and some lakes. As the road approaches the intersection with Chili Creek Road, it enters a mix of forests and farmland. After crossing the Tippah River, MS 5 reaches the MS 4 intersection and forms a concurrency with that route.

The two routes run through more rural areas as it leaves the boundaries of the Holly Springs National Forest, with the road passing some rural residences before reaching Ashland. Here, MS 4 splits from MS 5 by heading to the west, and MS 5 becomes Boundary Drive, which passes by businesses. The road intersects the western terminus of MS 370 as it continues through residential and commercial areas before leaving Ashland. The route heads into agricultural areas with some woodland and homes, making a turn to the northwest before resuming north. MS 5 comes to its northern terminus at an intersection with US 72 located to the south of Michigan City. MS 5 is legally defined in Mississippi Code § 65-3-3. The entire length of MS 5 is designated a scenic route by Chapter 316, Senate Bill 2547, Laws 1989.

What is now MS 5 originally existed as an unnumbered unpaved road by 1928. The MS 5 designation was assigned by 1932 for the road running from US 78 in Hickory Flat to the Tennessee border in Michigan City, where it connected to SR 18. This road was a gravel road south of Ashland and an earth road north of Ashland. By 1934, the portion north of Ashland became a gravel road. In 1943, the northern terminus of MS 5 was cut back to its current location at US 72, with MS 7 connecting to SR 18 at the Tennessee border. By 1948, the portion of route south of Ashland was paved. The remainder of the route was paved in 1951. Since then, the route has not undergone any alignment changes.

The entire route is in Benton County.