State Highway 107 or SH 107 is a state highway in the U.S. state of Texas that runs from Mission to Combes in Deep South Texas.

SH 107 begins at an intersection with US Route 83 in Mission and travels north through the center of town. It reaches an intersection with the old routing of US 83 and Texas State Highway 495 in Mission before exiting to the north. It passes through Palmhurst and Alton before turning right on Mile 7 Road. It then travels east through McAllen into downtown Edinburg, where it intersects the Business Route of US Route 281 and the current routing of US 281 just to the east. It continues east through rural farmlands, passing through the towns of Elsa, Edcouch, and La Villa. The route then turns southeast into Cameron County, passing through Santa Rosa. The then turn back to the east, reaching the intersection of Business Route 77 and the eastern terminus at the mainline of US 77 in Combes.

The highway was originally planned from Santa Anna to Brady by 1926. By 1928, this became an extension of SH 4. It was designated from Combes to Edinburg by 1933, and was complete by 1936. It was extended west then south through Mission to Hidalgo in 1939, absorbing State Highway 250. The route has changed little since then, with only the stretch from Mission to Hidalgo being transferred to FM 1016 in 1948.