State Highway 22, or SH 22, runs from Corsicana to Hamilton in north central Texas.

SH 22 was one of the 26 original state highways proposed in 1917, along a path from Wichita Falls to Comanche. By 1919, plans had been extended from Comanche eastward to Corsicana. Construction was slow, and by 1933, most of the section from Wichita Falls to Comanche had been reassigned to SH 79 and SH 67, while SH 22 ran from Hamilton to Timpson. By 1939, the part from Corsicana to Palestine had been transferred to US 287 and the part from Palestine to Timpson had been transferred to US 84, while SH 22 ran from Hamilton to Corsicana, and remained on this routing to this day.