State Highway 53 is a Texas state highway that runs from Temple to Rosebud.

SH 53 was designated by 1926 as a route from Dickens to Brownfield, replacing a portion of SH 18 (Dickens to Lubbock). This route was cancelled by 1933 when SH 24 extended west, replacing the route from Dickens to Lubbock, while the rest of the route was renumbered to SH 137. SH 53 was designated again by 1933 along a portion of the original route of SH 36 from Lampasas to Rosebud. It was shortened to its current route in 1935, when the stretch from Lampasas to Temple was transferred to U.S. Highway 190.