Wyoming Highway 22 (WYO 22, Teton Pass Highway) is a Wyoming state highway in Teton County. WYO 22 spans 17.53 miles (28.21 km) from Idaho State Highway 33 at the Idaho-Wyoming state line to the concurrency of U.S. Routes 26, 89, 189, and 191 (Broadway) in Jackson Hole, Wyoming.

Wyoming Highway 22 travels from the Idaho—Wyoming state line at Idaho State Highway 33 (the continuation into Idaho) and heads east. WYO 22 passes through Teton Pass, and later the community of Wilson, a census designated place (CDP). On the eastern border of Wilson, at 13.51 miles (21.74 km), WYO 22 intersects the southern terminus of Wyoming Highway 390 (Moose-Wilson Road) before crossing the Snake River. WYO 22 continues east to the town of Jackson where it ends at U.S. Highway 26/89/189/191 (Broadway).

WYO 22 used to connect to former Alternate US 20. That route used to begin at U.S. Highway 20 at Sugar City, Idaho. It followed Idaho State Highway 33 until the state line, then connected with WYO 22. Alternate US 20 used to end at the state line to connect and be redesignated as WYO 22, mainly because Wyoming didn't extend the route into the state. If that route were to be extended, it would have taken over the entire route of WYO 22, and overlap U.S. Highway 26 until it reached U.S. Highway 20 in Shoshoni.

The entire route is in Teton County.