Between its west terminus in Santa Monica, California and the East Los Angeles Interchange it is known as the Santa Monica Freeway. The Santa Monica Freeway is also called the "Rosa Parks Freeway" for the segment beginning at the San Diego Freeway (The 405 Freeway) and ending at the Harbor Freeway (The 110 Freeway), however either name can be used when referring to this stretch of road. The segment between the East Los Angeles Interchange and the city of San Bernardino, California (53 miles, or 92 km long) is known as the San Bernardino Freeway. Other names exist for the freeway. For example, a sign near the western terminus of the highway announces it as the "Christopher Columbus Transcontinental Highway". It is known to a considerably lesser degree as the "Veterans Memorial Highway" and is listed as a Blue Star Highway.
A stretch in Palm Springs is signed as the "Sonny Bono Memorial Freeway" as a tribute to the late entertainer who served both as mayor and as a United States Congressman. A second stretch a short distance east in Indio is signed as the "Doctor June McCarroll Memorial Freeway". As a nurse with the Southern Pacific Railroad in 1924, Dr. McCarroll was alarmed at the number of head-on traffic collisions on a nearby stretch of then-new U.S. Route 99, today known as State Route 86. She is credited with painting a white stripe down the middle of 99 near Coachella in order to separate the two lanes of traffic.
In Arizona, the highway is designated the "Pearl Harbor Memorial Highway". The portion through Phoenix is named the "Papago Freeway" and is a very vital piece of the regional freeway system. This designation starts at the initial junction/southern terminus of I-17 and runs westward out to AZ Loop 101, a loop route whose current western terminus is Interstate 10. Phoenicians more often than not refer to the freeway as "the I-10"(pronounced : the eye-ten).
From the southern terminus of Interstate 17 to the junction with the AZ Loop 202 freeway, the freeway is signed as the "Maricopa Freeway". This name holds true as well for I-17 from its southern terminus to its second junction with I-10, north of McDowell Road. From Loop 202 south to Interstate 8 (eastern terminus in Casa Grande), the freeway is signed as the "Pearl Harbor Memorial Highway". ADOT also has maps that show it as the Maricopa Freeway, while AAA and other sources show it as the Pima Freeway. The latter's name is used on a stretch of Loop 101 from U.S. 60 to Interstate 17.
In Tucson, the I-10 is called the Casa Grande Highway from the western edge of town to the eastern terminus of Business Loop 10, where it picks up the name, Tucson-Benson Highway from that route.
In Tucson, Arizona, between I-10 mileposts 259 and 260 are interchange ramps connecting I-10 with the northern terminus of Interstate 19 at its km post 100. I-19 leads 100 km south to its termination at the US-Mexico border at Nogales, Arizona (km post 0). Note that distance measurements on Interstate 19 are signed in metric units.
Also in Tucson, all exits between Prince Road and 22nd Street will be closed from June 2007 through spring 2010. I-10 is being widened from six to eight lanes, and seven bridges and underpasses are being built to deal with congestion. Plans are also under way to widen I-10 from Marana north to the I-8 interchange at Casa Grande from 4 lanes to 6 lanes starting in the later half of 2007 and continuing into 2008 and 2009.
Interstate 10 in New Mexico follows the former path of U.S. Route 80 across the state. Only three cities of significant size are located on the interstate: Lordsburg, Deming, and Las Cruces.
At Lordsburg is the western junction of U.S. Route 70 and a concurrency and the two highways are joined all the way to Las Cruces. Several exits between Lordsburg and Deming are either for former towns (including Separ, Quincy, and Gage) or lack any town at all.
At Deming is the western junction of U.S. Route 180, which also forms a concurrency with I-10 all the way to El Paso. One mile north of Deming on US 180 is New Mexico Route 26 which serves as a short cut to north I-25 and Albuquerque.
I-10/US 70/US 180 continue east to Las Cruces which is the southern end of Interstate 25. Also, US 70 leaves Interstate 10, heading northeast to Alamogordo. Interstate 10 then turns south to the Texas state line.
In Texas, the speed limit along I-10 from Kerr County to El Paso County is 80 mph (130 km/h), the highest in the nation. However, the nighttime maximum speed limit remains 65 mph (105 km/h).
From the state line with New Mexico to State Highway 20 in west El Paso, I-10 is bordered by frontage roads Desert South for lanes along I-10 East (actually headed south) and Desert North for lanes along I-10 West (headed north). The interstate then has no frontage roads for nine miles but regains them east of downtown and retains them to Clint. In this stretch, the frontage roads are Gateway East for the Eastbound lanes and Gateway West for the Westbound lanes. All four frontage roads are one way streets.
A small portion of I-10 from Loop 1604 to downtown in San Antonio is known as the Northwest Expressway or the McDermott Freeway, while another portion from downtown to Loop 1604 East is called East Expressway or Jose Lopez Freeway.
In Houston, from the western suburb of Katy to downtown, I-10 is known as the "Katy Freeway." This section is currently being widened to as much as 26 lanes (12 mainlanes, 4 lanes of access roads, and 4-6 mid-freeway HOT/HOV lanes, not counting access road turning lanes) and will be one of the widest freeways in the world. The section east of downtown Houston is officially known as the "East Freeway," although it is widely known by locals as the "Baytown East Freeway" due to a marketing push by Baytown, the easternmost principal city of the Greater Houston Area.
In Beaumont, it is designated Eastex Freeway between both splits with U.S. Highway 69. Eastex is not to be confused with the designation for U.S. Highway 59 in Houston.
In Louisiana, an 18.2-mile (29.3 km) stretch of elevated highway between Lafayette and Baton Rouge is known as the Atchafalaya Swamp Freeway, as it goes over the Atchafalaya River and the adjacent swamps and crosses the Mississippi River at the Horace Wilkinson Bridge. In Baton Rouge, Interstate 12 splits off to head north of Lake Pontchartrain and bypass Interstate 10's long southward jog through New Orleans and reconnects with Interstate 10 at Slidell. In New Orleans, a stretch of I-10 from the I-10/I-610 split near the Orleans-Jefferson parish line to the U.S. Route 90 / U.S. Route 90 Business interchange is known as the Pontchartrain Expressway. A dip near the 10-610 interchange to go underneath a railroad track is one of the lowest points in New Orleans, and is highly susceptible to flooding. Pictures of water dozens of feet deep during Hurricane Katrina are commonplace. Near Slidell, the final stretch of I-10 through the Mississippi state line is known as the "Stephen Ambrose Memorial Highway".
I-310 and I-510 are parts of what was slated to be I-410 and act as a southern bypass of New Orleans. I-610 is a shortcut from the eastern to western portion of New Orleans avoiding the I-10's detour into New Orleans' Central Business District.
Interstate 10 in Mississippi runs from the Louisiana state line to the Alabama state line through Hancock, Harrison and Jackson counties on the Gulf Coast. It passes through the northern sections of Gulfport and Biloxi while passing just north of Pascagoula. The highway roughly parallels U.S. Route 90.
I-10 crosses from Jackson County, Mississippi and goes through Mobile County in Southwest Alabama. In Mobile, the highway is the southern terminus for Interstate 65. In downtown Mobile, I-10 goes through one of few road tunnels in Alabama, the George C. Wallace Tunnel under the Mobile River. The eastbound approach is posted at 40 mph (60 km/h) because of the sharp curve approaching the tunnel. The highway then crosses approximately eight miles of the upper part of Mobile Bay on a bridge locals refer to as the Bayway. On the other side of Mobile Bay, the highway goes through suburban Baldwin County before crossing the Perdido River into Florida.
Most of Interstate 10 in Florida travels through some of the least-populated areas in the state, much of which is forested. Consequently, I-10 west of Interstate 295 in Jacksonville has only 4 lanes. In Pensacola, an approximately 3-mile stretch of I-10 is currently being widened to 6 lanes, which will be completed in 2007. A construction project also started in Tallahassee in October 2006 to widen I-10 to six lanes.
In Jacksonville, as in Arizona, I-10 is known as Pearl Harbor Memorial Highway. Throughout much of Florida, Interstate 10 is also known as State Road 8 or State Road 8A, though it is not signed as such.