Biloxi, Mississippi is close to the interstate highway I-10. It is neighboring other cities: D'Iberville, MS (2.8mi/6m ); Ocean Springs, MS (5.1mi/9m ); Gulfport, MS (12.8mi/23m ). You can get to the city from exit 46b a of i10 (4mi/7m ); exit 44 of i10 (6.3mi/11m ); exit 50 of i10 (7.3mi/12m ). Biloxi, Mississippi can reach interstate highways: i10 (4mi/7m ); i59 (57.4mi/1.5h ); i65 (58.5mi/1.1h ). It is also close to local highways: US 90 MS (0.5mi/1m ); MS 67 (4.6mi/9m ); MS 609 (5.1mi/9m ).