Lake City, Florida is close to the interstate highway I-10. It is neighboring other cities: Wellborn, FL (15.5mi/27m ); Fort White, FL (21.2mi/32m ); McAlpin, FL (20.9mi/37m ). You can get to the city from exit 435 of i75 (9.6mi/19m ); exit 301 of i10 (13.4mi/24m ); exit 303 of i10 (13.1mi/25m ). Lake City, Florida can reach interstate highways: i75 (9.6mi/19m ); i10 (13.4mi/24m ); i295fl (66.5mi/1.5h ). It is also close to local highways: FL CR COLUMBIA 242 (1.4mi/5m ); FL 247 (1.5mi/5m ); FL 47 (7.1mi/16m ).