Lake City, Florida is close to the interstate highway I-10. It is neighboring other cities: Wellborn, FL (13.60 mi ); Fort White, FL (20.72 mi ); Lulu, FL (21.38 mi ). You can get to the city from exit 435 of i75 (8.74 mi ); exit 301 of i10 (16.01 mi ); exit 303 of i10 (17.05 mi ). Lake City, Florida can reach interstate highways: i75 (8.74 mi ); i10 (16.01 mi ); i295fl (93.89 mi ). It is also close to local highways: FL CR COLUMBIA 242 (1.09 mi ); FL 247 (1.14 mi ); FL 47 (4.44 mi ).