Wilkes Barre, Pennsylvania is close to the interstate highway I-81. It is neighboring other cities: Georgetown, PA (1.5mi/5m ); Kingston, PA (1.8mi/5m ); Luzerne, PA (4.3mi/11m ). You can get to the city from exit 164 of i81 (4.6mi/9m ); exit 165b a of i81 (6.2mi/12m ); exit 159 of i81 (14.5mi/22m ). Wilkes Barre, Pennsylvania can reach interstate highways: i81 (4.6mi/9m ); i476pa (8.9mi/17m ); i80 (23.6mi/34m ). It is also close to local highways: PA 309 (2mi/5m ); PA 309 BUSINESS (2.2mi/6m ); PA 315 (3.2mi/7m ).