US 421 (KY) Travel Info
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U.S. Route 421 is a spur route of U.S. 21. It runs for 941 miles (1,514 km) from Michigan City, Indiana, at U.S. 20, to Fort Fisher in North Carolina. The highway goes through the cities of Indianapolis, Indiana, Lexington, Kentucky, Boone, North Carolina, Winston-Salem, North Carolina, Greensboro, North Carolina and ends in Wilmington, North Carolina.
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