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US 221 (NC) Travel Info


U.S. Route 221 in North Carolina runs north–south from the South Carolina state line to the Virginia state line in Western North Carolina.

US 221 enters from South Carolina as a rural highway, with mostly farms, wooded areas, or homes dotting the road. After 10 miles (16 km) it connects with US 74, where US 74 Business begins its overlap towards Rutherfordton ... more

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