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US 221 (SC) Travel Info

U.S. Route 221 (US 221) is a part of the United States Numbered Highway System that runs from Perry in northern Florida to Lynchburg in central Virginia. In South Carolina, the highway runs north to south from the Georgia state line near Clarks Hill to the North Carolina state line near Chesnee. While in the state, the highway passes through Greenwood, Laurens ... more

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