Florence, South Carolina is close to the interstate highway I-95. It is neighboring other cities: Darlington, SC (12.26 mi ); Effingham, SC (14.78 mi ); Timmonsville, SC (15.30 mi ). You can get to the city from exit 141b a of i20 (3.13 mi ); exit 160a of i95 (3.13 mi ); exit 160b of i95 (3.13 mi ). Florence, South Carolina can reach interstate highways: i20 (3.13 mi ); i95 (3.13 mi ); i77 (103.46 mi ). It is also close to local highways: SC 51 (1.27 mi ); US 52 SC (3.39 mi ); US 301 SC (6.26 mi ).